MOA of Tetracycline Antibiotics
MOA of Tetracycline Antibiotics Tetracycline Antibiotics Discovered in the late 1940s, tetracyclines are a family of broad-spectrum antibiotics used to treat a wide range of bacterial infections. The original tetracyclines were derived from Streptomyces bacteria, but the newer derivatives are semi-synthetic. Some representative tetracyclines include : · tetracycline · doxycycline · minocycline · panmycin · terramycin · trimocycline Tetracycline Mode of Action Tetracyclines exert their bacteriostatic effect by inhibiting protein synthesis in bacteria. This antibiotic prevents transfer- RNA (tRNA) molecules (a type of nucleic acids which transport amino acids) from binding to the 30S subunit of bacterial ribosomes. It is possible for tetracyclines to inhibit protein synthesis in the eukaryotic cells of the host, but the drug is less likely to reach the required concentra