ASIF BIOTECH

Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects. Tulsi in Hindi or Tulasi in Sanskrit (holy basil in English) is a highly revered culinary and medicinal aromatic herb from the family Lamiaceae that is indigenous to the Indian subcontinent and been used within Ayurvedic medicine more than 3000 years. Three types of tulsi are commonly described.  Ocimum tenuiflorum  (or  Ocimum sanctum  L.) includes 2 botanically and phytochemically distinct cultivars that include Rama or Sri tulsi (green leaves) and Krishna or Shyama tulsi (purplish leaves). while  Ocimum gratissimum  is a third type of tulsi known as Vana or wild/forest tulsi (dark green leaves) Metabolic Disorders Seventeen cl

ANTISENSE TECHNOLOGY An antisense oligonucleotide (ASO) is a single-stranded deoxyribonucleotide, which is complementary to the mRNA target. The goal of the antisense approach is the downregulation of a molecular target, usually achieved by induction of RNase H endonuclease activity that cleaves the RNA-DNA heteroduplex with a significant reduction of the target gene translation . Other ASO-driven mechanisms include inhibition of 5′ cap formation, alteration of splicing process (splice-switching), and steric hindrance of ribosomal activity . Drug # There are six FDA-approved drugs based on oligonucleotide therapy:- (1) fomivirsen for treatment of CMV retinitis in AIDS patients. (2) mipomersen for treatment of familial hypercholesterolemia. (3) Defibrotide for treatment of veno-occlusive disease in the liver. (4) eteplirsen for the treatment of Duchenne muscular dystrophy. (5) pegaptanib for the treatment of neovascular age-related macular degeneration. (6) nusinersen for

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Covid-19 Pathophysiology Introduction: In December 2019,WHO was informed of cases of pneumonia of unknown cause in Wuhan city,China.It was identified that the cause for the unusual pneumoniawas novel corona virus by Chinese authorities and was temporarily named “2019-nCoV”. A novel corona virus is a new strain that has not been previously identified in human.The  new virus was subsequently named as “COVID-19 Virus”.On March 11 2020, WHO director announced that the outbreak could be characterized as pandemic due to the rapid increase in number of cases outside china. Countries are racing to slow down the spread of virus.The pandemic is moving like a wave. Pathophysiology: The term Pathophysiology derived from Greek word “pathos”-suffering,”physis”-nature and “logos”-the study of.It refers to the study of deranged function in an individual or organ that are the causes,consequences of disease processes. Pathophysiological research aims at identifying factors and mechanisms tha